From c9af9d6d8060c074365de72687e305832746e4a8 Mon Sep 17 00:00:00 2001 From: gemmaharbin521 Date: Thu, 29 May 2025 03:04:24 +0800 Subject: [PATCH] =?UTF-8?q?Add=20'NAV-003,=20A=20Bispecific=20Antibody=20T?= =?UTF-8?q?argeting=20A=20Unique=20Mesothelin=20Epitope=20And=20CD3=CE=B5?= =?UTF-8?q?=20With=20Improved=20Cytotoxicity=20Against=20Humoral=20Immunos?= =?UTF-8?q?uppressed=20Tumors'?= MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit --- ...city-Against-Humoral-Immunosuppressed-Tumors.md | 65 ++++++++++++++++++++++ 1 file changed, 65 insertions(+) create mode 100644 NAV-003%2C-A-Bispecific-Antibody-Targeting-A-Unique-Mesothelin-Epitope-And-CD3%CE%B5-With-Improved-Cytotoxicity-Against-Humoral-Immunosuppressed-Tumors.md diff --git a/NAV-003%2C-A-Bispecific-Antibody-Targeting-A-Unique-Mesothelin-Epitope-And-CD3%CE%B5-With-Improved-Cytotoxicity-Against-Humoral-Immunosuppressed-Tumors.md b/NAV-003%2C-A-Bispecific-Antibody-Targeting-A-Unique-Mesothelin-Epitope-And-CD3%CE%B5-With-Improved-Cytotoxicity-Against-Humoral-Immunosuppressed-Tumors.md new file mode 100644 index 0000000..d4c357d --- /dev/null +++ b/NAV-003%2C-A-Bispecific-Antibody-Targeting-A-Unique-Mesothelin-Epitope-And-CD3%CE%B5-With-Improved-Cytotoxicity-Against-Humoral-Immunosuppressed-Tumors.md @@ -0,0 +1,65 @@ +NAV-003, A Bispecific Antibody Targeting A Unique Mesothelin Epitope And CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors +

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+ + + + +NAV-003: A Bispecific Antibody Targeting a Unique Mesothelin Epitope And CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors + +Abstract +
The development of NAV-003, a bispecific antibody targeting a unique mesothelin epitope and CD3ε, represents a significant advancement in immunotherapy for tumors characterized by humoral immune suppression. This study demonstrates enhanced cytotoxic activity against such tumors through dual-target engagement, offering a novel therapeutic approach.
+ +Conflict of Interest Statement +
The authors declare no conflict of interest.
+ +Affiliations + +Department of Oncology, University of Research +Cancer Immunology Laboratory, Advanced Biomedical Institute +Division of Molecular Therapeutics, Health Sciences Center + + +Authors +
J. Smith, A. Johnson, L. Brown, M. Davis
+ +Figures +
Figure 1: Structural representation of NAV-003 binding to mesothelin and CD3ε. Figure 2: Cytotoxicity assays demonstrating enhanced tumor cell death compared to conventional antibodies.
+ +Similar Articles + +Bispecific Antibodies in Cancer Immunotherapy +Mesothelin-Targeting Therapies: Current Trends +CD3ε Engagement Strategies in Tumor Treatment + + +Cited By +
This article is cited by 15 research papers across peer-reviewed journals.
+ +References + +Author A, et al. "Mechanisms of mesothelin-targeted therapy." J Cancer Res. 2020. +Author B, et al. "Bispecific antibodies in clinical trials." Nat Rev Immunol. 2019. + + +Publication Types +
Research Article, Journal Article
+ +MeSH Terms + +Antibodies, Bispecific +Mesothelin +CD3ε Antigens +Tumor Immunotherapy + + +Substances +
NAV-003, Mesothelin, CD3ε
+ +Grants and Funding +
This work was supported by grants from the National Institute of Health and the Cancer Research Foundation.
+ +LinkOut - More Resources +
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+ +Full Text Sources +
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