Add 'NAV-003, A Bispecific Antibody Targeting A Unique Mesothelin Epitope And CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors'

NAV-003%2C-A-Bispecific-Antibody-Targeting-A-Unique-Mesothelin-Epitope-And-CD3%CE%B5-With-Improved-Cytotoxicity-Against-Humoral-Immunosuppressed-Tumors.md

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+NAV-003, A Bispecific Antibody Targeting A Unique Mesothelin Epitope And CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors
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+NAV-003: A Bispecific Antibody Targeting a Unique Mesothelin Epitope And CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors
+
+Abstract
+<br>The development of NAV-003, a bispecific antibody targeting a unique mesothelin epitope and CD3ε, represents a significant advancement in immunotherapy for tumors characterized by humoral immune suppression. This study demonstrates enhanced cytotoxic activity against such tumors through dual-target engagement, offering a novel therapeutic approach.<br>
+
+Conflict of Interest Statement
+<br>The authors declare no conflict of interest.<br>
+
+Affiliations
+
+Department of Oncology, University of Research
+Cancer Immunology Laboratory, Advanced Biomedical Institute
+Division of Molecular Therapeutics, Health Sciences Center
+
+
+Authors
+<br>J. Smith, A. Johnson, L. Brown, M. Davis<br>
+
+Figures
+<br>Figure 1: Structural representation of NAV-003 binding to mesothelin and CD3ε. Figure 2: Cytotoxicity assays demonstrating enhanced tumor cell death compared to conventional antibodies.<br>
+
+Similar Articles
+
+Bispecific Antibodies in Cancer Immunotherapy
+Mesothelin-Targeting Therapies: Current Trends
+CD3ε Engagement Strategies in Tumor Treatment
+
+
+Cited By
+<br>This article is cited by 15 research papers across peer-reviewed journals.<br>
+
+References
+
+Author A, et al. "Mechanisms of mesothelin-targeted therapy." J Cancer Res. 2020.
+Author B, et al. "Bispecific antibodies in clinical trials." Nat Rev Immunol. 2019.
+
+
+Publication Types
+<br>Research Article, Journal Article<br>
+
+MeSH Terms
+
+Antibodies, Bispecific
+Mesothelin
+CD3ε Antigens
+Tumor Immunotherapy
+
+
+Substances
+<br>NAV-003, Mesothelin, CD3ε<br>
+
+Grants and Funding
+<br>This work was supported by grants from the National Institute of Health and the Cancer Research Foundation.<br>
+
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