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Pauling L: Speech at Natural Foods Exposition, March 29, 1982, reported in Pure Foods Merchandiser, June 1982, p.sixty five. The exception to the rule is the DOT1 family, members of which methylate K79 in the globular area of histone H3 and that are structurally not associated to SET-domain proteins four - 6 Latest work means that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)