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| This pore is rimmed with several structurally conserved carbonyl oxygens in addition to the hydroxyl group of the invariant tyrosine from the [carboxyl](https://search.un.org/results.php?query=carboxyl) terminus of the SET area (Determine 1 ). Promotes consumption of foods from the Paleolithic Period (foods from before agriculture) and demotes meals from the Neolithic Period (meals which might be products of agriculture). | |||||
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| Mutation of Tyr245 or Tyr305 in SET7/9 (Determine 4b ) alters its specificity from an H3 K4 mono-methylase to a tri- and di-methylase, respectively 16 , 21 , whereas an Phe281Tyr mutation within the lysine-binding pocket of DIM-5 (Determine 4c ) converts this protein to an H3 K9 mono- or di-methylase sixteen These mutations exemplify the F/Y switch (Figure 1 ) that establishes SET-area product specificities. | |||||
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