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Sunkist's orange soda has a surprising forty one milligrams of caffeine, and A&W Cream Soda has about 25 milligrams. The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-area proteins four - 6 Current work suggests that SET-area-containing proteins methylate a few proteins along with histones (see later)